Select Publications Related to mTORC1

mTOR Pathway and Nutrient Signaling

  • Bar-Peled, L. and Sabatini, D.M. Regulation of mTORC1 by Amino Acids. Trends in Cell Biology 24, 400 (2014).
  • Dibble, C.C. and Manning, B. Signal Integration by mTORC1 Coordinates Nutrient Input with Biosynthetic Output. Nature Cell Biol. 15, 555 (2013).
  • Efeyan, A. and Sabatini, D.M. Nutrients and Growth Factors in mTORC1 Activation. Biochem. Soc. Trans. 41, 902 (2013).
  • Proud, C.G. mTORC1 Regulates the Efficiency and Cellular Capacity for Protein Synthesis. Biochem. Soc. Trans. 41, 923 (2013).
  • Howell, J.J., Ricoult, S.J.H., Ben-Sahra, I. and Manning, B.D. A Growing Role for mTOR in Promoting Anabolic Metabolism. Biochem. Soc. Trans. 41, 906 (2013).
  • LaPlante, M. and Sabatini, D.M. Regulation of mTORC1 and its Impact on Gene Expression. J. Cell Sci. 126, 1713 (2013).
  • Johnson, S.C., Rabinovitch, P.S. and Kaberlein, M. mTOR is a Key Modulator of Ageing and Age-Related Diseases. Nature 493, 338 (2013).
  • Kim, S.G., Buel, G.R. and Blenis, J. Nutrient Regulation of the mTOR Complex 1 Signaling Pathway. Mol. Cells 35, 463 (2013).
  • Cornu, M., Albert, V. and Hall, M.N. mTOR in Aging, Metabolism and Cancer. Curr. Opinion in Genetics and Devel. 23, 53 (2013).
  • Bar-Peled, L. and Sabatini, D.M. SnapShot: mTORC1 Signaling at the Lysosomal Surface. Cell 151,1390 (2012).
  • LaPlante, M. and Sabatini, D.M. mTOR Signaling in Growth and Disease. Cell 149, 274 (2012).
  • Zhang, Y., Nicholatos, J., Dreier, J.R., et. al. Coordinated Regulation of Protein Synthesis and Degradation by mTORC1. Nature 513, 440 (2014).
  • Harputlugil, E., Hine, C., Vargas, D., et. al. The TSC Complex Is Required for the Benefits of Dietary Protein Restriction on Stress Resistance In Vivo. Cell Reports 8, 1160 (2014).


  • Heard, J.J., Fong, V., Bathaie, S.Z. Recent Progress in the Study of the Rheb Family of GTPases. Cellular Signalling 26, 1950 (2014).

mTOR Inhibition, Pharmacology and Disease

  • Li, J., Kim, S.G. and Blenis, J. Rapamycin: One Drug, Many Effects. Cell Metabolism 19, 1 (2014).
  • Kaberlein, M. mTOR Inhibition: From Aging to Autism and Beyond. Scientifica (Cairo) 2013, 849186 (2013).
  • Lamming, D.W., Ye, L., Sabatini, D.M. et al. Rapalogs and mTOR Inhibitors as Anti-Aging Therapeutics. J. Clin. Invest. 123, 980 (2013).
  • Vafai, S.B. and Mootha, V.K. A Common pathway for a Rare Disease? Science 342, 1453 (2013).
  • Johnson, S.C., Yanos, M.E., Kayser, E.-B. et al. mTOR Inhibition Alleviates Mitochondrial Disease in a Mouse Model of Leigh Syndrome. Science 342,1524 (2013).
  • Fang, Y., Westbook, R., Hill, C. et al. Duration of Rapamycin Treatment Has Differential Effects on Metabolism in Mice. Cell Metabolism 17, 456 (2013).
  • Wilkerson, J.E., Burmeister, L., Brooks, S.V. et al. Rapamycin Slows Aging in Mice. Aging Cell 11, 675 (2012).
  • Lamming, D.W., Ye, L., Katajisto, P. et al. Rapamycin-Induced Insulin Resistance is Mediated by mTORC2 Loss Uncoupled from Longevity. Science 335, 1638 (2012).
  • Benjamin, D., Colombi, M., Moroni, C. et al. Rapamycin Passes the Torch: a New Generation of mTOR Inhibitors. Nat. Rev. Drug Dis. 10, 868 (2011).
  • Bove, J., Vicente, M.M. and Vila, M. Fighting Neurodegeneration with Rapamycin: Mechanistic Insights. Nat. Rev. Neuroscience 12, 437 (2011).
  • Powell, J.D., Heikamp, E.B., Pollozzi, K.N. et al. A Modified Model of T-Cell Differentiation Based on mTOR Activity and Metabolism. Cold Spring Harb. Symp. Quant. Biol. published online October 7 (2013).
  • Chi, H. Regulation and Function of mTOR Signaling in T cell Fate Decisions. Nat. Rev. Immunology 12, 325 (2012).
  • Pryor, W.M., Biagioli, M., Shahani, N., et. al. Huntingtin Promotes mTORC1 Signaling in the Pathogenesis of Huntington’s Disease. Sci. Signaling a103. doi: 10.1126/scisignal.2005633 (2014).
  • Maiese, K. Taking Aim at Alzheimer’s Disease Through the Mammalian Target of Rapamycin. Ann. Med. doi: 10.3109/07853890.2014.941921 (2014).
  • Wahl, S.E., McLane, L.E., Bercury, K.K., et. al. Mammalian Target of Rapamycin Promotes Oligodendrocyte Differentiation, Initiation and Extent of CNS Myelination. J. Neurosci. 34, 4453 (2014).
  • Kassai, H., Sugaya, Y., Noda, S., et. al. Selective Activation of mTORC1 Signaling Recapitulates Microcephaly, Tuberous Sclerosis, and Neurodegenerative Diseases. Cell Reports 7, 1 (2014).
  • Shimobayashi, M. and Hall, H. making New Contacts: the mTOR Network in Metabolism and Signalling Crosstalk. Nat. Rev. Mol. Cell Biol. 15, 155 (2014).
  • Bercury, K.K., Dai, J.X., Sachs, H.H. et. al. Conditional Ablation of Raptor or Rictor Has Differential Impact on Oligodendrocyte Differentiation and CNS Myelination. J. Neurosci. 34, 4466 (2014).
  • Lipton, J.O. and Sahin, M. The Neurology of mTOR. Neuron 84, 275 (2014).
  • Sciarretta, S., Volpe, M. and Sadoshima, J. Mammalian Target of Rapamycin Signaling in Cardiac Physiology and Disease. Circ. Res. 114, 549 (2014).

Amino Acids, mTORC1 and Muscle Biology

  • Kimball, S.R. Integration of Signals Generated by Nutrients, Hormones and Exercise in Skeletal Muscle. Am. J. Clin. Nutr. 99(Suppl.), 237S (2014).
  • Proud, C.G. Control of the Translational Machinery by Amino Acids. Am. J. Clin. Nutr. 99(Suppl.), 231S (2014).
  • Taylor, P.M. Role of Amino Acid Transporters in Amino Acid Sensing. J. Clin. Nutr. 99(Suppl.), 223S (2014).
  • Bassil, M.S. and Gougeon, R. Muscle Protein Anabolism in Type 2 Diabetes. Curr. Opin. Clin. Nutr. Metab. Care 16, 83 (2013).
  • Brosnan, J.T. and Rooyackers, O. Amino Acids: the most versatile mutrients. Curr. Opin. Clin. Nutr. Metab. Care 16, 58 (2013).
  • Dickinson, J.M. and Rasmussen, B.B. Amino Acid Transporters in the Regulation of Human Skeletal Muscle Protein Metabolism. Curr. Opin. Clin. Nutr. Metab. Care 16, 638 (2013).
  • Dreyer, H.C., Strycker, L.A., Senesac, H.A. et al. Essential Amino Acid Supplementation in Patients Following Total Knee Arthroplasty. J. Clin. Invest. 123, 4654 (2013).

Sestrin Regulation of mTORC1

  • Chantranupong, L., Wolfson, R., Orozco, J.M., et. al. The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1. Cell Reports 9, 1 (2014).
  • Peng, M., Yin, N., Li, M.O., et. al. Sestrins Function as Guanine Nucleotide Dissociation Inhibitors for Rag GTPases to Control mTORC1 Signaling. Cell 159, 122 (2014).
  • Parmigiani, A., Nourbakhsh, A., Karin, M., Sestrins Inhibit mTORC1 Kinase Activation through the GATOR Complex. Cell Reports DOI: (2014).

Websites of Researchers:

Additional publications related to mTORC1 and nutrient signaling can be found on the laboratory websites of some of Navitor’s scientific advisory board members:

Sabatini Lab

Manning Lab

Rasmussen Lab